Articles
Squalene
Squalene, a 30-carbon isoprenoid, is a lipid found in large quantities in shark liver oil and in smaller amounts (0.1 to 0.7 %) in olive oil, wheat germ oil, rice bran oil and yeast. It is a key intermediate in the biosynthesis of cholesterol. Squalene is an all-trans isoprenoid containing six isoprene units. Chemically, it is known as (all-E)-2, 6, 10, 15, 19, 23-Hexamethyl-2, 6, 10, 14, 18, 22-tetracosahexaene.
What is Squalene?
The centrophorus artomarginatus deep sea sharks live in waters 600 to 1000 m deep, without sunlight. How can they manage to survive under such harsh conditions, where pressure is consistently high and oxygen supply is very poor?. The secret lies in their livers, which account for 25% to 30% of their total body weight.
The Biosynthetic Pathway of Squalene
Here you can see how important and irreplaceable is the pure Squalene in metabolism of cholesterol, steroids (sex hormones), bile acids and fat-soluble vitamins.